Rora^tm1.1Sbae
Targeted Allele Detail

Summary

• Symbol: Rora^tm1.1Sbae
• Name: RAR-related orphan receptor alpha; targeted mutation 1, Sung Hee Baek
• MGI ID: MGI:7489682
• Synonyms: RORalpha^flox
• Gene: Rora Location: Chr9:68561068-69295528 bp, + strand Genetic Position: Chr9, 37.45 cM
• Alliance: Rora^tm1.1Sbae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248803
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A FRT-flanked puromycin cassette containing a loxP sequence was inserted 5' to exon 4 and a single loxP site was inserted 5' to exon 5. The FRT-flanked puromycin cassette was removed via FLP-mediated recombination in the germline. (J:248803)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rora Mutation: 43 strains or lines available

References

• Original: J:248803 Kim K, et al., RORalpha controls hepatic lipid homeostasis via negative regulation of PPARgamma transcriptional network. Nat Commun. 2017 Jul 31;8(1):162
• All: 1 reference(s)