Trpm2^em1Jwji
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trpm2^em1Jwji
• Name: transient receptor potential cation channel, subfamily M, member 2; endonuclease-mediated mutation 1, Jianwei Jiao
• MGI ID: MGI:7489647
• Gene: Trpm2 Location: Chr10:77743556-77805746 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Trpm2^em1Jwji page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a termination codon near the start codon in the coding sequence. Western blotting and RT-PCR showed the absence of the encoded protein and transcript, respectively. (J:285409)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm2 Mutation: 111 strains or lines available

References

• Original: J:285409 Li Y, et al., Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia. Sci Adv. 2020 Jan;6(1):eaay6350
• All: 1 reference(s)