Sec13^tm1.2Bmaf
Targeted Allele Detail

Summary

• Symbol: Sec13^tm1.2Bmaf
• Name: SEC13 homolog, nuclear pore and COPII coat complex component; targeted mutation 1.2, Beatriz Fontoura
• MGI ID: MGI:7488429
• Synonyms: Sec13^fl
• Gene: Sec13 Location: Chr6:113705013-113717642 bp, - strand Genetic Position: Chr6, 52.84 cM, cytoband E3
• Alliance: Sec13^tm1.2Bmaf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted downstream of the 3' end of exon 9 and is flanked by two loxP sites. A single loxP site was also inserted upstream the 5 end of exon 7. The neomycin selection cassette was removed via flp-mediated recombination leaving exons 7-9 floxed. (J:336213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sec13 Mutation: 18 strains or lines available

References

• Original: J:336213 Liu Z, et al., Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling. J Clin Invest. 2022 Apr 1;132(7):e155096
• All: 1 reference(s)