Wif1^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Wif1^tm1.1Cya
• Name: Wnt inhibitory factor 1; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:7488427
• Synonyms: Wif1^loxP
• Gene: Wif1 Location: Chr10:120869909-120936547 bp, + strand Genetic Position: Chr10, 68.98 cM
• Alliance: Wif1^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336197
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a self-deletion anchor (SDA)-flanked neomycin cassette and second loxP site were inserted downstream of exon 3.The neomycin cassette was self-excised leaving exon 3 floxed. (J:336197)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wif1 Mutation: 33 strains or lines available

References

• Original: J:336197 Sun H, et al., Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease. Nat Commun. 2022 Mar 24;13(1):1600
• All: 1 reference(s)