Cldn5^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Cldn5^tm1.1Cya
• Name: claudin 5; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:7488426
• Synonyms: Cldn5^loxP
• Gene: Cldn5 Location: Chr16:18595597-18597012 bp, + strand Genetic Position: Chr16, 11.63 cM
• Alliance: Cldn5^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336197
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the first exon and a self-deletion anchor (SDA)-flanked neomycin cassette and second loxP site were inserted downstream of exon 1.The neomycin cassette was self-excised leaving exon 1 floxed. (J:336197)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn5 Mutation: 26 strains or lines available

References

• Original: J:336197 Sun H, et al., Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease. Nat Commun. 2022 Mar 24;13(1):1600
• All: 2 reference(s)