Cyp19a1^tm1.1Vdlm
Targeted Allele Detail

Summary

• Symbol: Cyp19a1^tm1.1Vdlm
• Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1.1, Ratna K Vadlamudi
• MGI ID: MGI:7486738
• Synonyms: Aro Flox, CYP19a1 loxP, Cyp19a1^tm1.1Geno
• Gene: Cyp19a1 Location: Chr9:54073221-54175394 bp, - strand Genetic Position: Chr9, 29.49 cM
• Alliance: Cyp19a1^tm1.1Vdlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274566
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 10 and 11 were flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted after the first loxP site, upstream of exon 10, and was removed via flp-mediated recombination. Exons 10-11 encode for the second substrate-binding site, the iron-binding site, part of the p450 domain, and the polyA signal. (J:274566)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp19a1 Mutation: 38 strains or lines available

References

• Original: J:274566 Lu Y, et al., Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory. J Neurosci. 2019 Apr 10;39(15):2792-2809
• All: 4 reference(s)