Runx2^tm1.1Taks
Targeted Allele Detail

Summary

• Symbol: Runx2^tm1.1Taks
• Name: runt related transcription factor 2; targeted mutation 1.1, Taku Saito
• MGI ID: MGI:7486227
• Synonyms: Runx2^fl
• Gene: Runx2 Location: Chr17:44806873-45125518 bp, - strand Genetic Position: Chr17, 21.33 cM
• Alliance: Runx2^tm1.1Taks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336057
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The targeting construct floxed exon 4. Recombination removed the selection cassette. (J:336057)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Runx2 Mutation: 44 strains or lines available

References

• Original: J:336057 Nagata K, et al., Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development. Nat Commun. 2022 Oct 19;13(1):6187
• All: 1 reference(s)