Mapk6^tm1.1Gsum
Targeted Allele Detail

Summary

• Symbol: Mapk6^tm1.1Gsum
• Name: mitogen-activated protein kinase 6; targeted mutation 1.1, Grzegorz Sumara
• MGI ID: MGI:7485892
• Synonyms: Erk3^fl
• Gene: Mapk6 Location: Chr9:75294064-75317303 bp, - strand Genetic Position: Chr9, 42.3 cM, cytoband E1
• Alliance: Mapk6^tm1.1Gsum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292510
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 3. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 3 floxed. (J:292510)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk6 Mutation: 29 strains or lines available

References

• Original: J:292510 El-Merahbi R, et al., The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. Genes Dev. 2020 Apr 1;34(7-8):495-510
• All: 2 reference(s)