Dusp6^tm1.2Skey
Targeted Allele Detail

Summary

• Symbol: Dusp6^tm1.2Skey
• Name: dual specificity phosphatase 6; targeted mutation 1.2, Stephen M Keyse
• MGI ID: MGI:7485835
• Gene: Dusp6 Location: Chr10:99099093-99103351 bp, + strand Genetic Position: Chr10, 51.13 cM, cytoband C3
• Alliance: Dusp6^tm1.2Skey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324774
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-betageo cassette flanked by loxP sites was inserted in intron 1 and a third loxP site was inserted downstream of the 3UTR. Cre-mediated recombination removed exons 2-3 and the betageo cassette. (J:324774)

Tumor Data

List all tumor models in MMHCdb carrying Dusp6^tm1.2Skey

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp6 Mutation: 30 strains or lines available

References

• Original: J:324774 Kidger AM, et al., Suppression of mutant Kirsten-RAS (KRAS(G12D))-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene. 2022 May;41(20):2811-2823
• All: 1 reference(s)