Bsn^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Bsn^tm1.2Arte
• Name: bassoon; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:7484797
• Synonyms: Bsn^ko, Bsn^tm2LIN
• Gene: Bsn Location: Chr9:107973221-108067583 bp, - strand Genetic Position: Chr9, 59.07 cM, cytoband F
• Alliance: Bsn^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316114
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by loxP sites and an FRT-flanked neomycin resistance gene was inserted in intron 1 and an F3-flanked puromycin resistance gene in intron 2. The neomycin and puromycin genes were removed via flp-mediated recombination. Exon 2 was deleted via cre-mediated recombination in the germline. (J:316114)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bsn Mutation: 148 strains or lines available

References

• Original: J:316114 Schattling B, et al., Bassoon proteinopathy drives neurodegeneration in multiple sclerosis. Nat Neurosci. 2019 Jun;22(6):887-896
• All: 3 reference(s)