Trpv6^tm1.1Pgg
Targeted Allele Detail

Summary

• Symbol: Trpv6^tm1.1Pgg
• Name: transient receptor potential cation channel, subfamily V, member 6; targeted mutation 1.1, Peter G Gillespie
• MGI ID: MGI:7484726
• Synonyms: M527-Trpv6
• Gene: Trpv6 Location: Chr6:41597558-41613339 bp, - strand Genetic Position: Chr6, 19.79 cM, cytoband B2
• Alliance: Trpv6^tm1.1Pgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263973
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A methionine to cysteine substitution at amino acid 527 (p.M527C) was introduced in exon 13 and a loxP-flanked neomycin resistance cassette was inserted downstream of exon 14. The neomycin resistance cassette was removed via cre-mediated recombination. This mutation has been shown to increase sensitivity to methanethiosulfonate reagents. (J:263973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv6 Mutation: 33 strains or lines available

References

• Original: J:263973 Morgan CP, et al., TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction. Front Cell Neurosci. 2018;12:41
• All: 1 reference(s)