Col17a1^tm1.2Zliu
Targeted Allele Detail

Summary

• Symbol: Col17a1^tm1.2Zliu
• Name: collagen, type XVII, alpha 1; targeted mutation 1.2, Zhi Liu
• MGI ID: MGI:7484701
• Synonyms: deltaNC16A
• Gene: Col17a1 Location: Chr19:47634783-47680460 bp, - strand Genetic Position: Chr19, 40.07 cM
• Alliance: Col17a1^tm1.2Zliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The mouse NC14A domain (exons 17-18) was replaced with the human NC16A counterpart encoded by exons 18 and 19, which were flanked by loxP sites. A FRT-flanked neo cassette was removed via flp-mediated recombination. Cre-mediated recombination removed exons 18 and 19, maintaining the reading frame and resulting in an NC16A domain-truncated protein. (J:263966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col17a1 Mutation: 54 strains or lines available

References

• Original: J:263966 Zhang Y, et al., BP180 dysfunction triggers spontaneous skin inflammation in mice. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6434-6439
• All: 3 reference(s)