Htr1a^tm4.1Rhn
Targeted Allele Detail

Summary

• Symbol: Htr1a^tm4.1Rhn
• Name: 5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 4.1, Rene Hen
• MGI ID: MGI:7484513
• Synonyms: fl1a
• Gene: Htr1a Location: Chr13:105580147-105584630 bp, + strand Genetic Position: Chr13, 56.92 cM
• Alliance: Htr1a^tm4.1Rhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254164
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: The single exon and the 3 untranslated region containing the polyadenylation signal were flanked by loxP sites. A modified yellow fluorescent protein, YPet, cDNA was inserted downstream of the 3 loxP site such that when the floxed region is removed, YPet is expressed under the endogenous Htr1a promoter. An inserted FRT-flanked PGK-EM7-Neomycin minigene was removed via flp-mediated recombination. (J:254164)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr1a Mutation: 25 strains or lines available

References

• Original: J:254164 Samuels BA, et al., 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response. Nat Neurosci. 2015 Nov;18(11):1606-16
• All: 4 reference(s)