Dgcr8^tm1.1Hmj
Targeted Allele Detail

Summary

• Symbol: Dgcr8^tm1.1Hmj
• Name: DGCR8, microprocessor complex subunit; targeted mutation 1.1, Hans-Martin Jack
• MGI ID: MGI:7484440
• Synonyms: DGCR8^fl
• Gene: Dgcr8 Location: Chr16:18071812-18107110 bp, - strand Genetic Position: Chr16, 11.31 cM, cytoband B1
• Alliance: Dgcr8^tm1.1Hmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246331
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a second loxP site, FRT-flanked neomycin resistance cassette, and third loxp site in opposite orientation were inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette leaving exon 3 floxed. (J:246331)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dgcr8 Mutation: 69 strains or lines available

References

• Original: J:246331 Brandl A, et al., The microprocessor component, DGCR8, is essential for early B-cell development in mice. Eur J Immunol. 2016 Dec;46(12):2710-2718
• All: 3 reference(s)