Fgfr2^tm1.2Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm1.2Sor
• Name: fibroblast growth factor receptor 2; targeted mutation 1.2, Philippe Soriano
• MGI ID: MGI:7484374
• Synonyms: Fgfr2^delta5
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm1.2Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241560
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector is designed to insert loxP sites at the 5' and 3' end of exon 5. The vector also included an FRT-flanked neomycin resistance (neo) cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. Exon 5 was deleted via cre-mediated recombination. (J:241560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 91 strains or lines available

References

• Original: J:241560 Molotkov A, et al., Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency. Dev Cell. 2017 Jun 05;41(5):511-526.e4
• All: 2 reference(s)