Cdkn1c^tm1Abes
Targeted Allele Detail

Summary

• Symbol: Cdkn1c^tm1Abes
• Name: cyclin dependent kinase inhibitor 1C; targeted mutation 1, Arnaud Besson
• MGI ID: MGI:7484339
• Synonyms: p57^CK-
• Gene: Cdkn1c Location: Chr7:143012076-143014735 bp, - strand Genetic Position: Chr7, 88.22 cM
• Alliance: Cdkn1c^tm1Abes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241179
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Four mutations, arginine to alanine at residue 33 (p.R33A) and phenylalanine to aspartate at residue 36 (p.F36D) in the cyclin binding domain, and tryptophan to alanine at residue 63 (p.W63A) and phenylalanine to aspartate substitution at residue 67 (p.K67D) in the CDK binding domain were introduced into exon 2. A loxP-flanked neomycin selection cassette was inserted downstream of exon 4. (J:241179)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn1c Mutation: 19 strains or lines available

References

• Original: J:241179 Duquesnes N, et al., p57(Kip2) knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann syndrome. J Pathol. 2016 Jul;239(3):250-61
• All: 2 reference(s)