Tg(Col1a1-Mgp*)4EDKry
Transgene Detail

Summary

• Symbol: Tg(Col1a1-Mgp*)4EDKry
• Name: transgene insertion 4ED, Gerard Karsenty
• MGI ID: MGI:7484121
• Synonyms: alpha1(I)Col-Mgpm2
• Transgene: Tg(Col1a1-Mgp*)4EDKry Location: unknown
• Alliance: Tg(Col1a1-Mgp*)4EDKry page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col1a1-Mgp*)4EDKry expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mgp (MGI:96976)	mouse promoter, modified mouse cDNA (p.E21D, p.E60D, p.E67D, p.E71D)

• Tg(Col1a1-Mgp*)4EDKry expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Col1a1 (MGI:88467)

• Mutation details: The transgene insert contains the following elements: 2.3 kb mouse Col1a1 gene proximal promoter sequence, modified mouse Mgp cDNA and SV40 poly(A) signal sequences. The modification involves changing glutamic acid codons 21, 60, 67 and 71 (GAA, GAA, GAG, GAG) to aspartic acid (p.E21D, p.E60D, p.E67D, p.E71D). (J:335627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:335627 Murshed M, et al., Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol. 2004 Jun 7;165(5):625-30
• All: 1 reference(s)