Tg(TAGLN-Mgp*)#Murs
Transgene Detail

Summary

• Symbol: Tg(TAGLN-Mgp*)#Murs
• Name: transgene insertion, Monzur Murshed
• MGI ID: MGI:7482757
• Synonyms: SM22alpha-GlamutMgp
• Transgene: Tg(TAGLN-Mgp*)#Murs Location: unknown
• Alliance: Tg(TAGLN-Mgp*)#Murs page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TAGLN-Mgp*)#Murs expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mgp (MGI:96976)	human promoter, modified mouse cDNA ( p.E21A, p.E60A, p.E67A, p.E71A)

• Tg(TAGLN-Mgp*)#Murs expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  TAGLN (6876)

  Tagln

  (MGI:106012)

• Mutation details: The transgene insert contains the following elements: 3 kb TAGLN gene proximal promoter sequence, mutated mouse Mgp cDNA and SV40 poly(A) signal sequences. The mutations involve changing glutamic acid codons 21, 60, 67 and 71 (GAA, GAA, GAG, GAG) to alanaine (GCA, GCA, GCG, GCG) (c.62A>C, c.179A>C, c.200A>C, c.212A>C, p.E21A, p.E60A, p.E67A, p.E71A), which prevents gamma-carboxylation of these residues in the encoded peptide. (J:326013)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:326013 Parashar A, et al., Prevention of Arterial Elastocalcinosis: Differential Roles of the Conserved Glutamic Acid and Serine Residues of Matrix Gla Protein. Arterioscler Thromb Vasc Biol. 2022 Jun;42(6):e155-e167
• All: 1 reference(s)