Lhcgr^em1Laj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lhcgr^em1Laj
• Name: luteinizing hormone/choriogonadotropin receptor; endonuclease-mediated mutation 1, Laurinda Jaffe
• MGI ID: MGI:7482672
• Synonyms: HA-LHR
• Gene: Lhcgr Location: Chr17:89023909-89099418 bp, - strand Genetic Position: Chr17, 58.35 cM
• Alliance: Lhcgr^em1Laj page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 endonuclease-mediated genome editing is used to insert a 9 amino acid (YPYDVPDYA) hemagluttin (HA) tag in N-terminus. In addition, the insertion included three silent point mutation located in the PAM site to eliminate recleavage. (J:292643)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lhcgr Mutation: 43 strains or lines available

References

• Original: J:292643 Baena V, et al., Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles. Endocrinology. 2020 Jul 1;161(7)
• All: 1 reference(s)