Tg(tetO-Islr)1Mat
Transgene Detail

Summary

• Symbol: Tg(tetO-Islr)1Mat
• Name: transgene insertion 1, Masahide Takahashi
• MGI ID: MGI:7482634
• Synonyms: TRE-Meflin
• Transgene: Tg(tetO-Islr)1Mat Location: unknown
• Alliance: Tg(tetO-Islr)1Mat page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The open reading frame of the mouse Islr (Meflin) gene was inserted into the multiple cloning site of a tetracycline-inducible expression vector pTRE3G followed by microinjection into fertilized eggs of C57BL/6 mice. Of four lines with germline transmission generated, one line was established based on the confirmed doxycycline-mediated induction. (J:322997)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:322997 Miyai Y, et al., Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade. Life Sci Alliance. 2022 Jun;5(6):e202101230
• All: 1 reference(s)