Trp53^tm3.1Umol
Targeted Allele Detail

Summary

• Symbol: Trp53^tm3.1Umol
• Name: transformation related protein 53; targeted mutation 3.1, Ute Moll
• MGI ID: MGI:7471421
• Synonyms: floxQ, p53^floxQ
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm3.1Umol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264731
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2, exons 4-9 were replaced with the orthologous human exons, the human exon 7 introduced contains a mutation resulting in an R248Q substitution, and an FRT and loxP site flanked neomycin resistance gene cassette was inserted into intron 10. Flp-mediated recombination removed the neo cassette leaving exons 2-10 floxed. (J:264731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 237 strains or lines available

References

• Original: J:264731 Alexandrova EM, et al., Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Nature. 2015 Jul 16;523(7560):352-6
• All: 3 reference(s)