Rfx4^tm1.1Pjb
Targeted Allele Detail

Summary

• Symbol: Rfx4^tm1.1Pjb
• Name: regulatory factor X, 4 (influences HLA class II expression); targeted mutation 1.1, Perry J Blackshear
• MGI ID: MGI:7471252
• Synonyms: Rbx4^flox
• Gene: Rfx4 Location: Chr10:84591926-84742402 bp, + strand Genetic Position: Chr10, 41.63 cM, cytoband C1
• Alliance: Rfx4^tm1.1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255626
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites. An adjacent frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in ES cells prior to the creation of mice. (J:255626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx4 Mutation: 48 strains or lines available

References

• Original: J:255626 Xu P, et al., Conditional ablation of the RFX4 isoform 1 transcription factor: Allele dosage effects on brain phenotype. PLoS One. 2018;13(1):e0190561
• All: 1 reference(s)