Clec4f^{tm1.1(HBGEF)Ciphe}
Targeted Allele Detail

Summary

• Symbol: Clec4f^{tm1.1(HBGEF)Ciphe}
• Name: C-type lectin domain family 4, member f; targeted mutation 1.1, Centre d'ImmunoPhenomique
• MGI ID: MGI:7469448
• Synonyms: Clec4f^tm1Ciphe, KC-DTR
• Gene: Clec4f Location: Chr6:83621524-83633098 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Clec4f^{tm1.1(HBGEF)Ciphe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236069
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An internal ribosome entry site-YFP-2A-human HBGEF-loxP-Cre-neoR-loxP cassette was introduced in the 3 untranslated region of the gene, downstream of the stop codon. Germline transmission led to the self-excision of the loxP-Cre-NeoR-loxP cassette in male germinal cells leaving the YFP and human diptheria toxin receptor gene. (J:236069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec4f Mutation: 28 strains or lines available

References

• Original: J:236069 Scott CL, et al., Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells. Nat Commun. 2016 Jan 27;7:10321
• All: 7 reference(s)