Ntsr1^tm1.1Kff
Targeted Allele Detail

Summary

• Symbol: Ntsr1^tm1.1Kff
• Name: neurotensin receptor 1; targeted mutation 1.1, Brigitte L Kieffer
• MGI ID: MGI:7468919
• Synonyms: NTSR1-Venus
• Gene: Ntsr1 Location: Chr2:180141769-180186772 bp, + strand Genetic Position: Chr2, 103.04 cM, cytoband H1-H4
• Alliance: Ntsr1^tm1.1Kff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert Venus yellow fluorescent protein cDNA into the C-terminal of the gene. A loxP-flanked neomycin resistance cassette associated with a Cre auto-excision transgene was inserted upstream of exon 4. This cassette allows the excision of the whole cassette in the chimera's male germ line. The endogenous gene is not affected by the insertion of the reporter. (J:335213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntsr1 Mutation: 34 strains or lines available

References

• Original: J:335213 Ehrlich AT, et al., Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice. Front Cell Neurosci. 2022;16:1076599
• All: 1 reference(s)