Gt(ROSA)26Sor^{tm1(CAG-Kcnj2,-tdTomato)Xyan}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Kcnj2,-tdTomato)Xyan}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Xin Yang
• MGI ID: MGI:7467517
• Synonyms: Kir2.1loxP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Kcnj2,-tdTomato)Xyan} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335141
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Kcnj2,-tdTomato)Xyan} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kcnj2 (MGI:104744)

• Mutation details: A construct containing CMV-IE enhancer/chicken-actin/rabbit beta-globin hybrid promoter (CAG), FRT site, loxP-flanked STOP cassette (with stop codons in all three reading frames and a triple poly(A) signal), flag-Kcnj2-2A-tdTomato sequence, WPRE, polyA signal, attB/attP-flanked PGK-FRT-neomycin cassette, and polyA was inserted between exons 1 and 2 of the locus. (J:335141)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:335141 Tian T, et al., Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism. Front Cell Neurosci. 2023;17:1114037
• All: 1 reference(s)