Gt(ROSA)26Sor^{em115(Stat3)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em115(Stat3)Smoc}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 115, Shanghai Model Organisms Center
• MGI ID: MGI:7467416
• Synonyms: Rosa26^{LSL-MLS-STAT3}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em115(Stat3)Smoc} page

Mutation origin

• Strain of Origin: C

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The COX IV sequence of yeast was utilized as the mitochondrial localization sequence (MLS). The CAG-LSL-MLS-Stat3-WPRE-pA vector was inserted into the Gt(ROSA)26Sor (Rosa26) locus by the CRISPRCas9 technique. (J:318741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:318741 Li R, et al., Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation. Theranostics. 2022;12(2):976-998
• All: 1 reference(s)