Arhgap29^em1Zlj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgap29^em1Zlj
• Name: Rho GTPase activating protein 29; endonuclease-mediated mutation 1, Zhong-Lin Jia
• MGI ID: MGI:7467171
• Synonyms: Arhgap29^R553T
• Gene: Arhgap29 Location: Chr3:121746752-121810326 bp, + strand Genetic Position: Chr3, 52.94 cM
• Alliance: Arhgap29^em1Zlj page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Arginine codon 553 (AGA) in exon 15 was changed to threonine (ACA) (p.R553T c.165G>C) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This mutation is the equivalent of the human p.R551T mutation found in some NSCL/P (non-syndromic cleft lip with or without the palate) patients. (J:328230)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap29 Mutation: 47 strains or lines available

References

• Original: J:328230 Li MJ, et al., Targeted re-sequencing on 1p22 among non-syndromic orofacial clefts from Han Chinese population. Front Genet. 2022;13:947126
• All: 1 reference(s)