Meioc^em1Rspi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Meioc^em1Rspi
• Name: meiosis specific with coiled-coil domain; endonuclease-mediated mutation 1, Ramesh S Pillai
• MGI ID: MGI:7466368
• Synonyms: Meioc^HA
• Gene: Meioc Location: Chr11:102556177-102573066 bp, + strand Genetic Position: Chr11, 66.48 cM
• Alliance: Meioc^em1Rspi page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutation: Insertion
• Mutation details: Sequence for an N-terminal double HA epitope tag was inserted in-frame immediately downstream of the ATG translation start codon in exon 1 using crRNA, tracrRNA and an ssODN template with CRISPR/Cas9 technology. (J:328765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meioc Mutation: 38 strains or lines available

References

• Original: J:328765 Li L, et al., The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m(6)A recognition. Mol Cell. 2022 May 5;82(9):1678-1690.e12
• All: 1 reference(s)