Bahcc1^em1Ggw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bahcc1^em1Ggw
• Name: BAH domain and coiled-coil containing 1; endonuclease-mediated mutation 1, Gang Greg Wang
• MGI ID: MGI:7466260
• Synonyms: Y2537A
• Gene: Bahcc1 Location: Chr11:120123773-120183108 bp, + strand Genetic Position: Chr11, 83.96 cM
• Alliance: Bahcc1^em1Ggw page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a TAC to GCT change resulting in a tyrosine to alanine substitution at amino acid 2537 (p.Y2537A). This is equivalent to the human mutation encoding p.Y2533A which disrupts H3K27me3 engagement. (J:334955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bahcc1 Mutation: 102 strains or lines available

References

• Original: J:334955 Fan H, et al., BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nat Genet. 2020 Dec;52(12):1384-1396
• All: 1 reference(s)