Eps8^em1Pgg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eps8^em1Pgg
• Name: epidermal growth factor receptor pathway substrate 8; endonuclease-mediated mutation 1, Peter G Gillespie
• MGI ID: MGI:7466157
• Synonyms: Eps8^delta818
• Gene: Eps8 Location: Chr6:137454242-137626262 bp, - strand Genetic Position: Chr6, 66.78 cM
• Alliance: Eps8^em1Pgg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a large deletion spanning 10,818 bp between exons 3 and 5. (J:334959)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eps8 Mutation: 122 strains or lines available

References

• Original: J:334959 Halford J, et al., Ca(2+) entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips. Mol Biol Cell. 2022 Apr 1;33(4):br6
• All: 1 reference(s)