Ank3^tm2.1Pmj
Targeted Allele Detail

Summary

• Symbol: Ank3^tm2.1Pmj
• Name: ankyrin 3, epithelial; targeted mutation 2.1, Paul M Jenkins
• MGI ID: MGI:7465152
• Synonyms: Ank3 W1989R
• Gene: Ank3 Location: Chr10:69234608-69863266 bp, + strand Genetic Position: Chr10, 36.1 cM
• Alliance: Ank3^tm2.1Pmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329513
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Tryptophan codon 1988 (TGG) in exon 37 was changed to arginine (CGG) (p.W1988R). This mutation is the equivalent of the human p.W1989R mutation found in some bipolar disorder (BD) patients. A loxP site flanked neomycin resistance gene cassette that was inserted into an intron was removed through subsequent Cre-mediated recombination. (J:329513)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ank3 Mutation: 171 strains or lines available

References

• Original: J:329513 Nelson AD, et al., Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. Mol Psychiatry. 2020 Nov;25(11):2800-2817
• All: 2 reference(s)