Shh^tm1.1Ahk
Targeted Allele Detail

Summary

• Symbol: Shh^tm1.1Ahk
• Name: sonic hedgehog; targeted mutation 1.1, Andreas H Kottmann
• MGI ID: MGI:7465089
• Synonyms: Shh-nLZ^C
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^tm1.1Ahk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A reporter construct (IRES, lacZ, polyadenylation sequence and floxed neo cassette) was inserted into the 3' untranslated region of exon 3. Cre-mediated recombination removed the neo cassette. The loxP-flanked regions and the lacZ are retained. (J:188348)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 48 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Shh^tm1Ahk, has been analyzed.

References

• Original: J:188348 Gonzalez-Reyes LE, et al., Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit. Neuron. 2012 Jul 26;75(2):306-19
• All: 3 reference(s)