Hdac10^em1Caox
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hdac10^em1Caox
• Name: histone deacetylase 10; endonuclease-mediated mutation 1, Xuetao Cao
• MGI ID: MGI:7465006
• Gene: Hdac10 Location: Chr15:89007510-89012903 bp, - strand Genetic Position: Chr15, 44.64 cM
• Alliance: Hdac10^em1Caox page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 3099-bp deletion encompassing exons 1-14, resulting in a frame-shift mutation and early termination of the encoded protein. (J:335000)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac10 Mutation: 38 strains or lines available

References

• Original: J:335000 Zhou W, et al., Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses. Sci Signal. 2022 Dec 20;15(765):eabo4356
• All: 1 reference(s)