Rbm20^{tm1d(KOMP)Eec}
Targeted Allele Detail

Summary

• Symbol: Rbm20^{tm1d(KOMP)Eec}
• Name: RNA binding motif protein 20; targeted mutation 1d, Esther Creemers
• MGI ID: MGI:7464987
• Gene: Rbm20 Location: Chr19:53665737-53855511 bp, + strand Genetic Position: Chr19, 48.28 cM
• Alliance: Rbm20^{tm1d(KOMP)Eec} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252765
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin and LacZ cassette together with loxP sites flanking exon 4 and 5 were inserted by homologous recombination. A null/knockout allele was created by subsequent flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked exons 4 and 5. (J:252765)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbm20 Mutation: 51 strains or lines available

References

• Original: J:252765 Khan MA, et al., RBM20 Regulates Circular RNA Production From the Titin Gene. Circ Res. 2016 Oct 14;119(9):996-1003
• All: 4 reference(s)