Trpm7^tm1.1Okak
Targeted Allele Detail

Summary

• Symbol: Trpm7^tm1.1Okak
• Name: transient receptor potential cation channel, subfamily M, member 7; targeted mutation 1.1, Koji Okabe
• MGI ID: MGI:7464933
• Synonyms: Trpm7^flox
• Gene: Trpm7 Location: Chr2:126633485-126718150 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband F2
• Alliance: Trpm7^tm1.1Okak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 17 and an FRT flanked PGK-neomycin cassette and second loxP site were inserted downstream of exon 17. The neomycin cassette was removed via flp-mediated recombination leaving exon 17 floxed. (J:330577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm7 Mutation: 101 strains or lines available

References

• Original: J:330577 Shin M, et al., Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis. Bone. 2022 Oct 7;166:116579
• All: 1 reference(s)