Tg(Per1-Kcnma1*R207Q)#Alme
Transgene Detail

Summary

• Symbol: Tg(Per1-Kcnma1*R207Q)#Alme
• Name: transgene insertion, Andrea L Meredith
• MGI ID: MGI:7464147
• Synonyms: Tg-BK^R207Q
• Transgene: Tg(Per1-Kcnma1*R207Q)#Alme Location: unknown
• Alliance: Tg(Per1-Kcnma1*R207Q)#Alme page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Per1-Kcnma1*R207Q)#Alme expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Kcnma1 (MGI:99923)	expresses mouse cDNA with R207Q mutation, driven by mouse promoter

• Mutation details: The transgene contains the following elements: a 6,756 bp DNA fragment containing the putative Per1 promoter sequence and the 5'-untranslated region, which encompasses exon 1 and part of exon 2, a modified Kcnma1 cDNA where arginine codon 207 was changed to glutamine (p.R207Q), and hemoglobin beta poly(A) signal sequences. This is a fast-activating gain-of-function mutation. (J:191740)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:191740 Montgomery JR, et al., Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18997-9002
• All: 1 reference(s)