F3^tm2Fct
Targeted Allele Detail

Summary

• Symbol: F3^tm2Fct
• Name: coagulation factor III; targeted mutation 2, Felix C Tanner
• MGI ID: MGI:7462664
• Synonyms: C213G Tf
• Gene: F3 Location: Chr3:121517186-121528697 bp, + strand Genetic Position: Chr3, 52.94 cM
• Alliance: F3^tm2Fct page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309113
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The coding region was replaced with a cDNA of the mouse gene containing a C213G mutation in exon 5 and a floxed neo cassette in inverse orientation via homologous recombination. This mutation disrupts the extracellular allosteric disulfide bond (Cys190-Cys213). (J:309113)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F3 Mutation: 24 strains or lines available

References

• Original: J:309113 Sluka SHM, et al., Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality. Haematologica. 2020 Oct 1;105(10):2484-2495
• All: 1 reference(s)