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F3tm2Fct
Targeted Allele Detail
Summary
Symbol: F3tm2Fct
Name: coagulation factor III; targeted mutation 2, Felix C Tanner
MGI ID: MGI:7462664
Synonyms: C213G Tf
Gene: F3  Location: Chr3:121517186-121528697 bp, + strand  Genetic Position: Chr3, 52.94 cM
Alliance: F3tm2Fct page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:309113
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Nucleotide substitutions
 
Mutation detailsThe coding region was replaced with a cDNA of the mouse gene containing a C213G mutation in exon 5 and a floxed neo cassette in inverse orientation via homologous recombination. This mutation disrupts the extracellular allosteric disulfide bond (Cys190-Cys213). (J:309113)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F3 Mutation:  24 strains or lines available
References
Original:  J:309113 Sluka SHM, et al., Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality. Haematologica. 2020 Oct 1;105(10):2484-2495
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory