Hmgb2^tm1Yaya
Targeted Allele Detail

Summary

• Symbol: Hmgb2^tm1Yaya
• Name: high mobility group box 2; targeted mutation 1, Yan Ynag
• MGI ID: MGI:7462656
• Gene: Hmgb2 Location: Chr8:57964941-57969033 bp, + strand Genetic Position: Chr8, 29.9 cM
• Alliance: Hmgb2^tm1Yaya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309120
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Three serine phosphorylation sites (Ser 422/423/425) in the C-terminus of the gene were mutated to alanine to eliminate phosphorylation and a floxed neo cassette was inserted via homologous recombination. The mutations were S422A (TCC to GCC), S423A (AGT to GCT), and S425A (TCT to GCT). (J:309120)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb2 Mutation: 10 strains or lines available

References

• Original: J:309120 Ding H, et al., Smad3 gene C-terminal phosphorylation site mutation aggravates CCl4 -induced inflammation in mice. J Cell Mol Med. 2020 Jun;24(12):7044-7054
• All: 1 reference(s)