Mef2d^tm1.2Jsca
Targeted Allele Detail

Summary

• Symbol: Mef2d^tm1.2Jsca
• Name: myocyte enhancer factor 2D; targeted mutation 1.2, J Simon C Arthur
• MGI ID: MGI:7461882
• Gene: Mef2d Location: Chr3:88049679-88079393 bp, + strand Genetic Position: Chr3, 38.78 cM
• Alliance: Mef2d^tm1.2Jsca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309142
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 2 exons were floxed and and FRT flanked neo cassette was inserted in intron 2 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exons 1 and 2. (J:309142)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mef2d Mutation: 63 strains or lines available

References

• Original: J:309142 Pattison MJ, et al., Loss of Mef2D function enhances TLR induced IL-10 production in macrophages. Biosci Rep. 2020 Aug 28;40(8)
• All: 1 reference(s)