Scnn1g^tm2Tkl
Targeted Allele Detail

Summary

• Symbol: Scnn1g^tm2Tkl
• Name: sodium channel, nonvoltage-gated 1 gamma; targeted mutation 2, Thomas R Kleyman
• MGI ID: MGI:7451012
• Synonyms: gamma^mt
• Gene: Scnn1g Location: Chr7:121333702-121367698 bp, + strand Genetic Position: Chr7, 65.07 cM
• Alliance: Scnn1g^tm2Tkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:334490
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The cDNA for the only known transcript of Scnn1g with a 3 V5 epitope tag and a neomycin resistance gene were inserted in frame, distal to the start codon in exon 2. Immunoblots of whole kidneys and lungs and Western blot analysis of kidney and lung lysates show reduced expression of the gamma-subunit in homozygotes, indicating this is a hypomorphic allele. (J:334490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scnn1g Mutation: 31 strains or lines available

References

• Original: J:334490 Ray EC, et al., Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC gamma-subunit expression. Am J Physiol Renal Physiol. 2021 Dec 1;321(6):F705-F714
• All: 1 reference(s)