C4b^em1Peng
Endonuclease-mediated Allele Detail

Summary

• Symbol: C4b^em1Peng
• Name: complement C4B (Chido blood group); endonuclease-mediated mutation 1, Bo Peng
• MGI ID: MGI:7450929
• Synonyms: C4b^-
• Gene: C4b Location: Chr17:34947354-34962856 bp, - strand Genetic Position: Chr17, 18.29 cM
• Alliance: C4b^em1Peng page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9-mediated genome editing, exons 1 and 2 of the C4b gene were targeted to generate C4b indel mutants with >83% frameshift indels. (J:330602)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C4b Mutation: 106 strains or lines available

References

• Original: J:330602 Zhou T, et al., Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nat Commun. 2022 Oct 24;13(1):6233
• All: 1 reference(s)