Gt(ROSA)26Sor^{em1(CAG-Dusp7)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Dusp7)Smoc}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:7450805
• Synonyms: Rosa26CAG-Dusp7, Rosa26^LSL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Dusp7)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A CAG promoter, loxP-flanked 5xpolyA (STOP) cassette, Kozak-Dusp7 with a 3xFlag tag, and WPRE and polyA cassette was inserted into the locus using CRISPR/Cas9 technology. (J:334132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:334132 Liu J, et al., Dual Specific Phosphatase 7 Exacerbates Dilated Cardiomyopathy, Heart Failure, and Cardiac Death by Inactivating the ERK1/2 Signaling Pathway. J Cardiovasc Transl Res. 2022 Dec;15(6):1219-1238
• All: 1 reference(s)