Shisa6^tm1.2Sasp
Targeted Allele Detail

Summary

• Symbol: Shisa6^tm1.2Sasp
• Name: shisa family member 6; targeted mutation 1.2, Sabine Spijker
• MGI ID: MGI:7448971
• Synonyms: Shisa6^{tm1b(Caliper)CNCR-VUA}
• Gene: Shisa6 Location: Chr11:66102551-66416790 bp, - strand Genetic Position: Chr11, 40.55 cM
• Alliance: Shisa6^tm1.2Sasp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236346
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was flanked by loxP sites and an FRT-flanked neomycin cassette was inserted downstream of the floxed exon. The neomycin cassette was removed via flp-mediated recombination. Exon 1 was deleted via flp-mediated recombination. (J:236346)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shisa6 Mutation: 15 strains or lines available

References

• Original: J:236346 Klaassen RV, et al., Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity. Nat Commun. 2016 Mar 02;7:10682
• All: 2 reference(s)