Tg(Epo-cre)1Weng
Transgene Detail

Summary

• Symbol: Tg(Epo-cre)1Weng
• Name: transgene insertion 1, Roland H Wenger
• MGI ID: MGI:7448899
• Synonyms: Epo-^CreERT2, Epo-Cre^ERT2#1, Tg(EPO::Cre)nRhw
• Transgene: Tg(Epo-cre)1Weng Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Tg(Epo-cre)1Weng page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Epo-cre)1Weng expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Epo (MGI:95407)

• Mutation details: The Cre/ERT2 cDNA sequence was targeted into the 2nd exon and 4th intron of the mouse Epo gene in the BAC clone RP24-338L14. Eight independent founder lines were generated and two of them (lines #1 and #241) were further analyzed by whole genome sequencing. Line #1 is inserted into the chr14. (J:334336)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Epo (mouse) Summary of all recombinase alleles driven by Epo. Comparative matrix view of recombinase activities Alliance mouse Epo gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:334336 Imeri F, et al., Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation, and a telocyte phenotype. Kidney Int. 2023;95:375
• All: 1 reference(s)