Dis3^em1Dean
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dis3^em1Dean
• Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; endonuclease-mediated mutation 1, Jurien Dean
• MGI ID: MGI:7447487
• Synonyms: Dis3^em1Jdean, Dis3-flox
• Gene: Dis3 Location: Chr14:99314070-99337217 bp, - strand Genetic Position: Chr14, 49.25 cM, cytoband E2.1
• Alliance: Dis3^em1Dean page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct is designed using CRISPR/cas9 genome editing to insert a loxP site upstream of exon 3 and a loxP site downstream of exon 5. (J:333824)

Expression

In Mice Carrying this Mutation:

5 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dis3 Mutation: 41 strains or lines available

References

• Original: J:333824 Wu D, et al., Persistent pervasive transcription in RNA exosome depleted oocytes results in loss of female fertility. bioRxiv. 2022
• All: 3 reference(s)