S100a8^tm1Lex
Targeted Allele Detail

Summary

• Symbol: S100a8^tm1Lex
• Name: S100 calcium binding protein A8 (calgranulin A); targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:7447415
• Gene: S100a8 Location: Chr3:90576378-90577341 bp, + strand Genetic Position: Chr3, 39.9 cM, cytoband F1-F2
• Alliance: S100a8^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241074
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• A 529 bp region containing exons 2 and 3 was replaced by a LacZ/neomycin selection cassette. (J:283601)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S100a8 Mutation: 10 strains or lines available

References

• Original: J:241074 Laouedj M, et al., S100A9 induces differentiation of acute myeloid leukemia cells through TLR4. Blood. 2017 Apr 06;129(14):1980-1990
• All: 3 reference(s)