Mc4r^em1Vai
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mc4r^em1Vai
• Name: melanocortin 4 receptor; endonuclease-mediated mutation 1, Christian Vaisse
• MGI ID: MGI:7447189
• Synonyms: Mc4r-GFP, MC4R-GFP, Mc4r^tm1(egfp)Vai
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^em1Vai page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: A GFP is inserted in frame following the 5 flanking sequence of the MC4R coding sequence by CRISPR-Cas9. (J:261694)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 46 strains or lines available

References

• Original: J:261694 Siljee JE, et al., Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018 Feb;50(2):180-185
• All: 3 reference(s)