Mlkl^em2Xidw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em2Xidw
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 2, Xiaodong Wang
• MGI ID: MGI:7447137
• Synonyms: MLKL S441A
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em2Xidw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a TCC to GCT change resulting in a serine to alanine substitution at amino acid 441 (p.S441A). Two synonymous mutations were also introduced to avoid Cas9 cleavage. (J:334165)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 32 strains or lines available

References

• Original: J:334165 Guo J, et al., Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2121552119
• All: 1 reference(s)