Clba1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clba1^em1(IMPC)J
• Name: clathrin binding box of aftiphilin containing 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7446962
• Gene: Clba1 Location: Chr12:112772595-112779865 bp, + strand Genetic Position: Chr12, 61.2 cM
• Alliance: Clba1^em1(IMPC)J page
• IMPC: Clba1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GCACATCTAAAACCCTGTCG and CTTAGCTCGGAACTGCGCCG, which resulted in a 378 bp deletion beginning at Chromosome 12 position 112,774,279 bp and ending after 112,774,656 bp (GRCm39/mm39). This mutation deletes ENSMUSE00000306390 (exon 2) and 241 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 140 and early truncation 1 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Clba1 Mutation: 13 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 1 reference(s)