Cd274^em1Xmd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd274^em1Xmd
• Name: CD274 antigen; endonuclease-mediated mutation 1, Xiao-ming Deng
• MGI ID: MGI:7446742
• Synonyms: PD-L1^flox
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^em1Xmd page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology generated a floxed allele. No information is provided on region flanked by loxP sites. (J:315687)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 71 strains or lines available

References

• Original: J:315687 Wang JF, et al., Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis. Blood. 2021 Sep 2;138(9):806-810
• All: 3 reference(s)